Что делать если ослабла потенция


  • Indications for use
  • Acceptance of use
  • Negative reactions
  • Contraindications
  • Cooperation with other medicinal products
  • Overdose
  • Savings properties
  • Appearance of the issue
  • Structure
  • In addition

Erectile restores the disturbed ability to obtain and maintain an erection and gives a normal removes sexual desire. Sildenafil acts as a permanent and selective inhibitor of cgmp-specific phosphodiesterase type 5 (pde-5), which is responsible for the collapse of cgmp in the cavernous body. The drug stimulates the release of nitric oxide (no) in the cavernous body during sexual activity, activating guanylate cyclase, and inhibits pde-5. Note that the level of cgmp quality significantly increases, which provokes relaxation of smooth muscles and increased blood circulation in the cavernous body.Pharmacokinetics. Quickly absorbed after feeding inside. The concentration of sildenafil in the blood plasma after oral administration on an empty stomach reaches the highest value during 30-120 minutes (mostly 60 minutes). The absolute bioavailability at ingestion is generally 41% (25-63%). The pharmacokinetics of sildenafil during intravenous administration in the recommended dose range (25-100 mg) is linear. When erectil is used together with fatty foods, the rate of absorption decreases, the interval for reaching cmax increases by 50 minutes, and cmax in blood plasma drops by about 29%. Sildenafil is metabolized especially under the influence of sur 3a4 (major) and sur 2c9 (minor pathway) microsomal liver isoenzymes. The half-life takes approximately 4 hours. Sildenafil is usually excreted in the form of derivatives with feces (about 60% or to a small extent-with urine (about 13%).

Indications for use

The drug erectil is used for ed.

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